I just came across your post and found it interesting. I have had MS Office 2010 installed for a year now and have only used Word and OutLook. However, I think that One Note will be useful now that I am beginning an activity that will require the keeping of many and varied source materials, the majority of which will come from the internet.
When I opened One Note for the first time today it asked if I wanted to sync it to the Web and the option was accompanied by the words (Recommended). So, I chose to sync with the web and was required to enter my Windows Live ID.
Though I haven't used it yet I think my choice to sync with the web was a good one. Hopefully, when I find material online that I want to save and add to One Note regarding my new activity I will be able to do it via the right click drop down menu. This will save me a lot of copying and pasting, etc..