I have some ISOs where whenever I mount them and select "Play DVD" in the autoplay menu, an Error box comes up with the message "E:/ Application not found"
This also happens if I doubleclick on the DVD or right-click and select play.
However, If I open Windows Media Player and access the DVD though it, the movie plays fine.
I don't now what I did to cause this, maybe when I took out my video card (but I don't know if the problem popped up at the same time). It use to work perfectly fine.