A couple things I noticed that IE 10 can't do.
It will not allow me to update my routers firmware when using IE10 but IE9 still works for this. Obviously this is for security reasons but none the less we need to be able to do these things with our browsers.
IE10 also does not allow me to run my .gws file which is a router settings file to restore all router settings with. I have to use IE9 for this also.
These are standard files for router maintenance yet for some reason Msoft has left us out in the cold here.
I did mess with the security setting to no avail.