Nice OC.
What are you wanting the memory to be at 1066 or 1333?
With the CPU Clock speeds, you Memory should be just fine a 1000mhz.
EDIT:
I just realized 8GB.
If you have all 4 DIMM slots full, this will certainly make it a bit harder to OC. Being as its 1333 RAM, you should be able to get to run at that speed or lower.
You can run a quick Mem test to get a quick idea what kind of bandwidth you have.
Elevated CMD Prompt --> Winsat Mem
You may be just as well off leaving it at 1000mhz, or lower the CPU clocks if you must.
Im not all that familiar with AMD overclocking, but being as the memory controllers are on the chip ... my guess is it will require more Vcore to try and stabilize the RAM at higher speeds.
But I have no idea where you max voltages are.
Perahaps those with more AMD experience will be of more help
@ 4.0Ghz I would think 53C under Prime would be more than acceptable. Remember, youll never stress your PC that hard in a real world situation, so you probably will never see it get that warm even under heavier use.
At any count .. looking good so far.