Keep it simple.
What may work is set you RAM to its rated Speed/timings/voltages and test it with Memtest before you do anything. Make sure its good.
If thats OK, set the CPU multi to 45, set vCore to 1.3v. Most should be able to run at 4.5 here. If yours wont, increase a little at a time until stable.
If its OK at those voltages, then start lowering it and testing until you find the lowest stable vcore.
You may also want to set VDroop to "Without vDroop" OR enable Load Calibration.
(whatever your board calls the setting that reduces/eliminates vDroop)
But as mentioned, not all CPUs are the same and your really better off just taking your time and find what your setup likes.
Mine runs at 4.5 with 1.25 Volts. You may need less, a bit more, or a lot more. Theres no way to know.