I am having exactly the same issue on a user's PC. The machine seems to run fine, but she has this error in the log every 4 seconds going back as far as I can see.
The reason that I found the error in the first place was that the user is having trouble connecting to sites via remote desktop, and restarting always seems to resolve the issue for a while.
Whatdaya think? Related?
Update: I tried the solution recommended in the response above, but ran into a roadblock at "registry value: HKCR\Clsid\clsid value\localserver32" which does not exist on that machine.