Your post doesn't really tell that much apart from your uncle using MSE as the AV.
The posts above are really good but rather than go straight in with "optimising this and that" l would start off with the basics first.
If you haven't got them already, download the following free software -
CCleaner
Glary Utilities 1 click maintenance
SuperAntiSpyware
Malwarebytes
I'm not sure whether l'm allowed to post links to these but you'll find them via google anyway.
Before you run each one, check for their updates first.
Once you've run them, and they have "done their thing", you can either choose to keep them, which is
advisable, or you can remove them via the control panels remove programs option.
Then go to start, type in msconfig, and select the msconfig entry.
When you get the System Configuration Panel up, select the startup tab. The only tab that really needs to be ticked for now is your AV. Uncheck all others, select ok, and you'll probably need to reboot.
After all of that, then see how your uncle's laptop goes!