Repeated Events warning re something open in my registry file

I can only provide information because I don't understand this. However, it's a repeated events warning and I have been painstakingly dealing with many problems on this computer for many months. With a lot of help from this forum I feel like I'm almost home but this repeated message doesn't sound "right". And I am still living with "this program has stopped responding" although it now seems limited to Outlook 2010 rather than all MS programs.

Win 7 Prof 64 bit SP1 up to date. Cable modem bought myself Motorola Surfboard newest model. Apple Extreme router. I frequently use DNS other than those provided by my ISP for obvious reasons :)

Run Eset NOD and MBam as well as windows firewall. I also have five hard drives on the system all of which test ok. Two SSDs and three WD black caviars.

Here is the full copy of the "warning" - several times a day:

Code:

Log Name:      Application
Source:        Microsoft-Windows-User Profiles Service
Date:          12/13/2012 1:58:11 AM
Event ID:      1530
Task Category: None
Level:         Warning
Keywords:      
User:          SYSTEM
Computer:      mg-PC
Description:
Windows detected your registry file is still in use by other applications or services. The file will be unloaded now. The applications or services that hold your registry file may not function properly afterwards.  

 DETAIL - 
 1 user registry handles leaked from \Registry\User\S-1-5-21-3328621373-938311138-4019764245-1001:
Process 740 (\Device\HarddiskVolume1\Windows\System32\winlogon.exe) has opened key \REGISTRY\USER\S-1-5-21-3328621373-938311138-4019764245-1001

Event Xml:
<Event xmlns="http://schemas.microsoft.com/win/2004/08/events/event">
  <System>
    <Provider Name="Microsoft-Windows-User Profiles Service" Guid="{89B1E9F0-5AFF-44A6-9B44-0A07A7CE5845}" />
    <EventID>1530</EventID>
    <Version>0</Version>
    <Level>3</Level>
    <Task>0</Task>
    <Opcode>0</Opcode>
    <Keywords>0x8000000000000000</Keywords>
    <TimeCreated SystemTime="2012-12-13T06:58:11.198177600Z" />
    <EventRecordID>118456</EventRecordID>
    <Correlation />
    <Execution ProcessID="420" ThreadID="3584" />
    <Channel>Application</Channel>
    <Computer>mg-PC</Computer>
    <Security UserID="S-1-5-18" />
  </System>
  <EventData Name="EVENT_HIVE_LEAK">
    <Data Name="Detail">1 user registry handles leaked from \Registry\User\S-1-5-21-3328621373-938311138-4019764245-1001:
Process 740 (\Device\HarddiskVolume1\Windows\System32\winlogon.exe) has opened key \REGISTRY\USER\S-1-5-21-3328621373-938311138-4019764245-1001
</Data>
  </EventData>
</Event>

I hope this is the correct information to provide and would appreciate any and all suggestions/recommendations.

Madeline