If the program doesn't offer you to select where you want to install it during it's installation, then it would be best to leave them alone. It usually doesn't work out well when trying to move the Program Files folder.
If you like, you could do this below to save some space by moving files in your user folders (ex: My Music, My Documents, etc....) to a folder where you like to access from your libraries with the files actually located where you like instead.
In addition, you might see if this tutorial below may be able to help save you some more space. Hard Disk Space - Free Up and Recover
Hope this helps,