Running out of room

It seems I'm running out of disk space in the C: drive. I have a Dell Optiplex 760, Dual-Partitioned tower using Windows 7 Pro OS and 64-bit. Other than removing any unnecessary programs, using CCleaner, SmartDefrag and TFC, is there ANYTHING else I can do to significantly reduce the amount of space in my C: drive? Already, I'm starting to see that the system is slowing down. Are there items in the C: drive, downloaded files, program files, etc. that can be removed to free up some space? (And, if that be the case, is there a simple way to determine whether a file can be removed or whether it can't be without adversely affecting the system?)

Attached are screenshots (2) of both C: and E: drives.

Thank you anyone who can participate with some suggestions.

Shawn, thanks so much for this NEAT program. Just ran it and the results are incredible. I've attached three (3) screenshots of the size results from the right column, since I had to "piece" them together.
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Brink said:

Hello Larry,

You might see if the tutorial below may be able to help with freeing up some HDD space. Using Option 1 with the free program WinDirStat is a good first start to see exactly what is using the space.

Hard Disk Space - Free Up and Recover

Hope this helps, :)
Shawn

Brink said:

You're most welcome Larry. I hope it helps you to find anything that could be safely deleted to free up more space.

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Shawn, from the top of the lists I just sent as attachments, you'll notice that the top items take up the most memory. To your knowledge, is there anything that can be removed?

Very well, Shawn. Thanks so much for your help.