Extremely Poor Wireless Mouse Performance In-Game?

I have a Microsoft Wireless Mouse 4000 that I frequently carry around. I would like to try using it to play games, but it has serious issues. Outside of a game, the mouse works perfectly fine. In game, the mouse jerks around and stutters, making it utterly impossible to use. It does not occur with any wired USB mouses.

what game?

Borderlands. I'll try it on other titles and post back shortly.

EDIT: All games seem to do it, including Bad Company 2, Dead Space 2, Fallout New Vegas, and Modern Warfare 2.

Have you attempted updating the drivers for that mouse?

Microsoft Wireless Mouse 4000 | Microsoft Hardware