Cursor going outside the game in dual monitor setup

Quite often I find with games on a dual monitor setup is that Id find the cursor is on the other monitor and if I accidentally click there I lose focus of the game and some games wont tab back in.

Is there any way to prevent the cursor going outside the game in fullscreen?

Not that i know, you can turn it off while your playing?

Has to be a cheaper way but if you don't have it Ultramon,

Realtime Soft UltraMon

can do just that with a hotkey combo.