I just tried out the Glarysoft tool. I only can advice to be careful. It can't really do anything that CCleaner can't do or that you can do with the Windows 7 tools. I can uninstall software without extra tools. I also can defrag on my own. Here
you find a summary on what to use and do. Except of Kaspersky every tool you will ever need is free. It is nice for a non-advanced user to have all windows built-in tools in one tool, but unfortunately it comes with some poisonous pills and even advanced users fall for the registry cleaner tricks.
I tried the registry cleaner as I advice against those. by default it almost goes right to deleting things when you are not careful. Although the things it tried to delete didn't look too dangerous, I don't see reason to risk it. It is snake oil anyway.
Even when it still works after registry cleaning, it could be something you don't use right away and in some week you find yourself reinstalling some software.
The same with the memory optimizer. Yeah, MS doesn't know how to use the memory and has superfetch and other things and bringing this tool in fore sure will improve things
the only good thing about the tool is that it is free.
Maybe the shredder and un-deleting function are useful. But I'm sure there are better tools and having this full "optimization" suite tempts the user to use all the dangerous "optimizations".
all this applies to TuneUp and other such software as well. You don't need it.. unless you plan on re-installing your OS every once a while.