There are some good anti virus apps. with antispyware add ons , but none are perfect.
It is a good idea to have a specialized anti-spyware app. in addition to your regular antivirus - even if it has antispyware added on.
I do occasional on-demand scans with Malwarebytes, just for an extra level of safety - in addition to Windows Defender
Ad-aware and Spybot are also well respected.