It totally possible to do.
I only set it to 1366x769.
If you have all displays can be set to 1920x1080 then you are good to go.
But there are few basic thing we should know.
There are 4 modes in sending video signal from our PC (you can normally see by pressing start menu button +P)
1. Computer only (first monitor)
2. Duplicate (Only run with similar resolution)
4. Projector only
We have to make sure what is the optimal resolution of each display (best if it all have the same resolution) then if you set it to duplicate we won't have any problem with it. On setting 1 and 4 we can set individual resolution after selecting it
(but it will be back to common resolution if we set it back to duplicate).
If you use DVI splitter it will work by the same resolution. Make sure that you have good quality DVI cables if the other displays are more than 5 meters away from your PC. you have to connect it securely.
The problem is that you at the same time have to extend sound input cables (with DVI).
If you are using ATI HD series VGA card, it has additional utility to set, but I have no knowledge of it
Edit: If you connect second monitor with lower resolution than your PC will pick the lower one.