I have used Kaspersky and found it a bit complicated for the settings.
MSE (Microsoft Security Essentials) is on a couple of my systems, but it is not without fault.
Free AVG we have used at our computer club and it was a disaster.
ESET was recommended by Corrine
and she is one of the world leading AV experts. Visit her Security garden
On my production systems I use Norton Internet Security and it has never failed in the last 4 years.