Yes, it DOES work on my RTM 64bit Windows 7 system. If you like the interfacce, then that's great. I'll be interested to see how it stacks up against some of the other packages out there, once finally released. In the passed McAfee has been renowned for false alarms and not catching some malware that it should have. Don't know about now though...
Where I work, it is the corporate 'standard' issue and the first of us to get "7" also took on the beta of "Mc2010". They actually release a build of 2009 that worked fine in my 64bit "7" too, but that was only out for a few weeks before 2010 arrived.
It is doing a full background scan as I type this and reports it is 28% though (66,000 files so far) since about 9am - now 10:40am, but I have it working in the background. If I stop typing it'll speed up scanning, if I type, it'll slow down it's scanning and take longer as a result. I need to take a L..O..N..G break and let it finish - must go to a meeting I think!!!
UPDATE: Just left the PC alone (no activity from me) for two minutes and it went from 28% to 30% complete on a scan that will need to examine 140Gb. Does that help you when it comes to seeing how fast/slow that aspect of it works?