If you mean the free Malwarebytes, yes you can and should. The free Malwarebytes is used as a weekly scan and there is not real time protection and no conflict. If there is a conflict you can set up both pieces of software to ignore each other. Malwarebytes specializes in Malware (adware, etc). Take if from me, for that extra protection, use both.
Personally, I prefer Microsoft Security Essentials over Kaspersky. Security Essentials is one of the few A/V that I have not seen cause BSODs on Windows.