Windows 7: Best anti virus today?

Look into true cloud based AV solutions. I am going to cite Webroot again because instead of downloading the virus definitions to your computer, it scans from the definitions hosted in the cloud.

How does a cloud based AV work if the internet connection is unavailable?
What happens if a malicious program is installed when there is no internet connection?

Your main protection while disconnected from the internet will be coming from SecureAnywhere's behavioral shields/detections and local heuristics.

There are a very limited amount of locally held definition signatures for certain critical items that don't require reaching the cloud. These are mainly for rare file infectors. Anything that is known as good from prior scans (while previously connected to the internet) will still be known as good if they have not changed when performing scans offline, which explains the speed of the scan.

Also, if a program or process was being monitored before going offline, it will continue to be monitored and these processes and their behavior will still be journaled. This journaling allows SecureAnywhere to keep an eye on possibly malicious programs or processes it was unsure about, and if they try to execute or end up being an actual threat, the damage done can be reverted.

Malwarebytes is a scanner, not an AV program. That together with SuperAntiSpyware makes for good scanners. The best I know.

+1 I'm running Avast Interenet Security 2012, Malewarebytes Pro, and Superantispyware together and have had zero conflicts or problems!!!