If this is for a home, then it would be simpler to move the shortcuts from all users start menu* to the admin profile(s)**. However, hiding the shortcuts by moving them or via GPO (if there is a way to do that) would not stop users from starting the program via the Windows (file) Explorer.
GPO can restrict a user from running a program. In theory, this should work no matter how the user attempts to run the forbidden program. In reality, they are ways to start some programs restricted by GPO. That is why I wondered if this is for a home - then we might be talking about adults vs. children.