Deep Infection?

I am just short of doing a clean install of the system. With the help of Layback Bear over in General discussions I have got my machine running better than it was, but there are still signs that things are not as they should be. I built this machine to be a screamer, but I am not a gamer so what I do should not be a burden at all.

What I have done:
Uninstalled all IOBIT and Norton products. (This in itself really sped things up)
Installed MSE and MalwareBytes Pro.
Run full system scans with both MSE and MB along with SFC/Scannow. All scans showed everything to be peachy.

What is happening:
the biggest problem has been with my browsers. Chrome runs by far the best, but still is slow and not fining pages I know should be there. IE just sits there if I paste an address in the bar, I can search to sites, but links may or may not work and sometimes opens a new tab and other times opens a new window. Totally erratic behavior. I have not tried Firefox but I am fairly certain it would give similar results.
Programs are just not as snappy as they should be and when you are in an "open file" mode the search window inconsistently flashes from arrow to hula-hoop.
The device manager window flashes about once a second. I have two USB Controllers Under Unknown devices with yellow warnings. One is located on PCI bus 3 and the other on PCI bus 6. Iacan delete them but they pop uo again on reboot.

I get no error messages or warnings.

What I have learned:
The very things I was paying good money for for system protection have been my worst enemy.

Any suggestions before I wipe the system and start over would be greatly appreciated.

WOW!!! That really helped a lot I ran the disk check and that did find a few problems, I then ran the adwcleaner and hope I did it correctly. I first ran the search, and then ran it again using the delete option. I installed superantispyware and ran a scan and found 122 problem, mostly tracking cookies.
Your not kidding about the TDSSKiller download ref being hard to find. But I eventually found it and ran it but it came up clean.

The difference in my browsers is amazing. There are a few issues remaining. Chrome is running very well, but I will have to give it some time to see if one problem persists. I had forgot to mention that if I have had chrome open for a while or had a lot of tabs open, when I would exit out it would freeze my machine for up to 10 minutes.
I don't know if I have just not used IE for a long time and not doing things right, but the address bar seems broken. If I type or paste and address in, it just sits there. Suggestions pop up but again if I click on one it still just sits there. But if I begin with a search it does very well and opens links now where it did not before.

Thank you very much ICit2lol

Thanks! Here is the resulting file.

Thanks VistaKing! Hopefully I have everything. I was a bit confused by the hitmanPro results screen which said "No Threats found" and then underneath that said Threats found: 780. But here are the resulting files...

Yo are the man! IE will now open links from e-mails and the address bar works. Chrome will need some time to test, but I did open several tabs and then shut it down and boom it was gone whereas before it it would hang for at least a second or two. And it got worse as time went on.
Thanks tons for your help!