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#51
The Best Anti-Virus IMO is
1. Keep Windows and all your other programs up to date.
2. Don't play on the Net where Malware tends to hang out.
3. Clean your temp and cache files each day when done browsing.
4. Don't open any downloaded files directly. Rather save and scan them first.
4. Don't open any email attachments unless you know the sender and are expecting an email from him/her with an attachment.
After that all the leading AVs are about equal enough IMO it is a matter of personal taste as to GUI and ease of use.