Here are my suggestions:
Config #1
Layer No.1 (Prevention)
- Enable LUA/UAC and DEP for all applications.
- Online Armor Premium (firewall with classical HIPS) - easy to use, many notifications/prompts from HIPS module implemented in OA. // or Outpost Firewall Pro (also with classical HIPS)
Layer No.2. (Detection)
- Avira AntiVir Premium
- MBAM/SAS (as on-demand scaners)
Layer No.3. (Cure) - on-demand.
- Paragon Drive Backup or StorageCraft Shadow Protect Desktop or just use Windows 7 backup feature (image backup)
- Karen Replicator or SyncBack Freeware (data backup), both freeware but very reliable applications.
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Config #2
Layer No.1 (Prevention)
- Enable LUA/UAC and DEP for all applications.
- DefenseWall Personal Firewall v3 (currently in Release Candidate state) - very powerful security application, it's policy based sandbox + HIPS, but it's not classical HIPS so it gives only critical prompts i.e. access to resources, keylogging, access to clipboard, etc...
Layer No.2. (Detection)
- Avira AntiVir Premium or Avira AntiVir Free (compare to Premium, version Free doesn't have http scaner, and updates are limited to one per day plus with every update you will see advertising Avira window, but it is stiil good alternative since detection in Free version is almost the same as in Premium version)
- MBAM/SAS (as on-demand scaners)
Layer No.3. (Cure) - on-demand.
- Paragon Drive Backup or StorageCraft Shadow Protect Desktop or just use Windows 7 backup feature (image backup)
- Karen Replicator or SyncBack Freeware (data backup), both freeware but very reliable applications.