I believe in my commercial solution. Eset NOD32 Antivirus 6 + Agnitum Outpost Firewall Pro". gave defender and MSE good to go away
MSE is good, but for my satisfaction this is better. note that both of those have complete security products, it's just after a lot of testing i found that nod is better antivirus than agnitum and agnitum has way better firewall than eset. you decide what's your best solution!
also make difference between free and commercial. MSE is i think the best free solution (though you have to have genuine windows? :P), but i like to pay for eset and agnitum cause they made my life easy for years!