Hi elm27,
I think Reykjavik - sorry, jimbo45

- is correct and I am assuming that you are talking of the Virtual CloneDrive in a non-virtual machine problem.
The first question I would ask is "Wherefrom did you download the Virtual CloneDrive?"
One
possiblity is that your antivirus program is not permitting it to run and is responsible for that error message.
Well, that can be a real virus infliction that came with a virus-laden download or a virus from some other source. The solution to try: get rid of that program and get rid of the virus.
If your download is from a reputed site like
SlySoft Virtual CloneDrive - always download from the software author's website to the extent possible - , then I will reframe the question " What anti-virus program do you have on your machine?"
The solution to try is: disable your antivirus program and check. If confirmed that it is stopping the VCD run, add Virtual CloneDrive to the exceptions list in your Anti-Virus program as a permanent fix - if that is possible.
Or
get rid of the antivirus program and go with Microsoft Security Essentials. ( I have Virtual CloneDrive and MSE.)
Note: I have clearly told that this is one possibility. There may be other reasons that I may not know still.