Like piattj & Mike I do not install all updates all at once. I know I could. But I don't.
I install in groups:
All the securities at once
Then all the general Updates
Then any IE's
Then .NETs - one at a time.
Then any optionals
The one time I broke this rule the .NETs got screwed up. Turned a 5 min job into a 30 min job

. Never again!