System crashing

Further problems
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ok, as a result of the previous reply I have wiped and reinstalled completely Windows 7 onto the system. I am running Trendmicro and it is not reporting any virus related issues.
I wiped the C: Drive and then installed off of the retail version of Windows 7 Home Premium.
The install ran without errors and then has applied a series of Windows updates. and rebooted. Every thing is ok so far.
I rerun the memory checker and no issues being reported. I download the latest and greatest Nvidia driver for my GTX 460 from the vendor.
I reinstall my Game DDO.
Ok the fun starts up again. I am not getting hard hangs but I am getting BSOD with dumps multiple times per hour now. I will happen while playing my game.. Could be 2 minutes or over an hour. No specific pattern I can identify.
When I run the windbg on the dumps it is telling me that the fault is in various different system drivers. One time the USB driver. Another the NT kernel, and also the Nvidia 3D driver(which I an not using 3d), so and so forth.... So I suspect disk issue / corruption.
I purchase Sandra home pro and run the various benchmark and disk reporting tools. No issues identified by Sandra.
I have windows run the diskcheck on the reboot. Once again no issues reported.
So what ever the issue appears to be systemic and not software but rather hardware. (my opinion and can be wrong).
So can anyone point me in the direction of what I should try next in my troubleshooting.
I have thought about removing each disk and reinstalling windows seperately to verify if it is a disk specific issue, but this seems a bit extreme and I know that windows will yell at me for installing multiple times and force me into the windows activation h@ll.
Any guidance would be greatly appreciated.
Thanks Bruce
While I am no longer getting the event 41 errors I am getting application errors
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Original issue:

BSOD Event 41 need help
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Is Windows 7 Home Premium- x64 ?- Custom Build original OS installed on machine
- full retail version - What is the age of system (hardware)? 3 Years- What is the age of OS installation 2 years

Have been getting BOSD, Hard Freezes, and reboots periodicly about once per week. As of this last week I am now getting the same issue once or more per day. In the event viewer it is just reporting event id 41.
I have run memory checkers to verify that the memory is not the issue.
CPU was running hot and I had to remove the stock cooler and clean the surface and reapplied liquidd silver and a new Zalman cooling system. Temp was running in the 60 Celius but after repairing it is runing in the high 30's Celcius.
Any help on how to identify the cource of the issue would be appreciated.