Mouse and or keyboard randomly stop working

Thank you. We should do some USB troubleshooting first.

• Start with USB Driver - General Fix for Problems to resolve the USB issues. Also, USB ports can sometimes enter a safe power state to protect the system from power surges due to USB devices. To reset the USB ports to a nominal power state:
  
  1. Shut down and turn off the computer.
     
  2. Unplug the computer from the wall or surge protector (then remove the battery if it is a laptop).
     
  3. "Remove the computer from any port replicator or docking station, disconnect
     cables to printers or devices such as external monitors, USB memory sticks or SD cards, headset or external speakers, mouse or auxiliary keyboard, turn off WIFI and Bluetooth wireless devices." (Use Hard Reset to Resolve Hardware and Software Issues HP Pavilion dv5000 Notebook PC series - HP Customer Care (United States - English))
     
  4. Hold down the power button for 30 seconds. This closes the circuit and ensures all
     power from components is drained to clear the software connections between the BIOS
     and hardware and clear any corruption in the temporary memory.
     
  5. (If it is a laptop, plug the battery back into the laptop and then) Plug the computer back into the wall. Do not reconnect any unnecessary peripherals; monitor, keyboard,
     and mouse should suffice and be the only peripherals reconnected.
     
  6. Turn it on to reinitialize the software connections between the BIOS and hardware
     

I had the problem where my usb mouse and usb keyboard would lock up on windows 7. New machine, old usb mouse and cheap $11 keyboard spilled in and buttons fell off. I tried different USB ports and could get it so only my keyboard would lock up. Read it might be the keyboard to reinstall operating system due to deep internal glitch...I read some stuff and then finally found what made the most since. Control Panel device manager under usb hubs power management a box was checked that allowed it to turn off the usb device to save power. Unchecked those on all those since i use the mouse and keyboard all the time. All better.