Desk
Floor
Mine sits on the right hand edge of my desk. I have a heavy case as well, the Antec P180. I think it's around 50lbs with everything in it. It doesn't sit on the floor as my computer is in the basement and I don't want to take any chances of the basement taking in any water. I may built a small little stool for it to sit on at some point to get it off my desk.
I place mine atop some old emachine towers that reside on the floor next to my computer desk.
I can't really vote, as I alternate between the floor and the desk. It varies on what I'm doing also, and what room I am in.
In my bedroom I usually have the desktop I use on a desk. In the living room however I would put it on the floor, don't know why.
(I almost put bathroom instead of bedroom. lol)
I mainly use my laptop though
on the table
On a TV stand, next to my (mis~appropriated lab table) desk: Puts the media drives right at arms reach, and aims the fans below the tabletop so they're less obnoxious.
I may go liquid cooling for the next build - if only to make the thing quieter.
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