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#11
Adding to other suggestions to check for malware, I'd also recommend Malwarebytes Free. Update the database and run a full scan. It seems to catch things others miss.
Malwarebytes : Malwarebytes Anti-Malware is a free download that removes viruses and malware from your computer
You may have somehow lost ownership of your files preventing them from being opened.
Take Ownership Shortcut
If ownership is not a problem you might consider using Adobe's latest and greatest PDF program called Adobe Reader X. Or another freebie called Nitro PDF Reader.
PDF reader, protected mode | Adobe Reader X
Nitro PDF Reader