Will it be safe to delete this files/folders?

Sorry for being a dummy, after using TreeSize Free, I saw the files/folders that are consuming so much space in C: the question is, will it be safe to delete them? Here they are:

I specified them to not confuse them with others
I'm losing space(maybe 1gig above) without downloading something and TreeSize was recommended so I used it also after playing I 'always' use CCleaner:Secure file deletion advanced overwrite(I don't even know if this differs from normal) and registry cleaner(I'll just fix all issues) and Disk Cleanup ran it as admin and I'm still losing space though not that big e.g.
as I check: 90 gb
later or tomorrow: 89.7 gb
day after tomorrow: maybe 88 gb
Someone out there not harsh on noobs and can 'basically' advise me why should or shouldn't I delete them?

@pebbly - Thanks for the advice
@Bongo - Thank you also, I decreased the Disk Space Usage to 1%, deleted the restore points and turned off the system protection will it still continue eating space?(I won't be needing restore points)

@pebbly - Okay I don't want to regret something XD is it okay to set Disk Space Usage to 1% and to 'only restore previous version of files'? Btw will the allocated space be returned as free/usable space?

pebbly said:

Yes and Yes

Thanks for everything!