Strange glitches in W7- a Virus?!

Hi n2gc, Please find below posted report from Combo Fix. I would be grateful for any comments.
I noticed problems with Google Chrome locking-up or slowing right down recently too.
Gregrocker, sounds like a bit of an extreme solution- the problem is I don't have really large chunks of time to fix this, which a clean installation etc. as you are suggesting would necessitate. But it might come to that eventually, so thanks. :)

ComboFix 12-07-14.01 - Chris J. Hudson 15/07/2012 16:45:23.1.2 - x86
Microsoft Windows 7 Home Premium 6.1.7601.1.1252.44.1033.18.3071.2031 [GMT 1:00]
Running from: c:\users\Chris J. Hudson\AppData\Local\Microsoft\Windows\Temporary Internet Files\Content.IE5\XVK1OVWM\ComboFix.exe
AV: Kaspersky Internet Security *Disabled/Updated* {2EAA32A5-1EE1-1B22-95DA-337730C6E984}
FW: Kaspersky Internet Security *Disabled* {1691B380-548E-1A7A-BE85-9A42CE15AEFF}
SP: Kaspersky Internet Security *Disabled/Updated* {95CBD341-38DB-14AC-AF6A-08054B41A339}
SP: Windows Defender *Enabled/Updated* {D68DDC3A-831F-4fae-9E44-DA132C1ACF46}
* Created a new restore point
.
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((((((((((((((((((((((((( Files Created from 2012-06-15 to 2012-07-15 )))))))))))))))))))))))))))))))
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2012-07-15 15:52 . 2012-07-15 15:52 -------- d-----w- c:\users\UpdatusUser\AppData\Local\temp
2012-07-15 15:52 . 2012-07-15 15:52 -------- d-----w- c:\users\Default\AppData\Local\temp
2012-07-15 15:52 . 2012-07-15 15:52 -------- d-----w- c:\users\CHRISJ~1~HUD\AppData\Local\temp
2012-07-15 15:28 . 2012-07-15 15:28 -------- d-----w- C:\TDSSKiller_Quarantine
2012-07-14 08:03 . 2012-07-15 15:52 56200 ----a-w- c:\programdata\Microsoft\Windows Defender\Definition Updates\{7776427F-A57B-4626-AD7B-283D4E09345A}\offreg.dll
2012-07-14 06:13 . 2012-05-31 03:41 6762896 ----a-w- c:\programdata\Microsoft\Windows Defender\Definition Updates\{7776427F-A57B-4626-AD7B-283D4E09345A}\mpengine.dll
2012-07-13 08:28 . 2012-05-04 09:59 514560 ----a-w- c:\windows\system32\qdvd.dll
2012-07-13 08:24 . 2012-07-13 08:24 -------- d-----w- C:\SkyDriveTemp
2012-07-11 21:07 . 2012-06-12 02:40 2345984 ----a-w- c:\windows\system32\win32k.sys
2012-07-11 20:36 . 2012-06-02 04:45 67440 ----a-w- c:\windows\system32\drivers\ksecdd.sys
2012-07-11 20:36 . 2012-06-02 04:45 134000 ----a-w- c:\windows\system32\drivers\ksecpkg.sys
2012-07-11 20:36 . 2012-06-02 04:40 369336 ----a-w- c:\windows\system32\drivers\cng.sys
2012-07-11 20:36 . 2012-06-02 04:40 225280 ----a-w- c:\windows\system32\schannel.dll
2012-07-11 20:36 . 2012-06-02 04:39 219136 ----a-w- c:\windows\system32\ncrypt.dll
2012-07-11 20:36 . 2012-06-06 05:05 1390080 ----a-w- c:\windows\system32\msxml6.dll
2012-07-11 20:36 . 2012-06-06 05:05 1236992 ----a-w- c:\windows\system32\msxml3.dll
2012-07-11 20:36 . 2010-06-26 03:24 2048 ----a-w- c:\windows\system32\msxml3r.dll
2012-07-11 20:35 . 2012-06-06 05:05 1019904 ----a-w- c:\program files\Common Files\System\ado\msado15.dll
2012-07-11 20:35 . 2012-06-06 05:05 143360 ----a-w- c:\program files\Common Files\System\ado\msjro.dll
2012-07-11 20:35 . 2012-06-06 05:05 372736 ----a-w- c:\program files\Common Files\System\ado\msadox.dll
2012-07-11 20:35 . 2012-06-06 05:05 57344 ----a-w- c:\program files\Common Files\System\ado\msador15.dll
2012-07-11 20:35 . 2012-06-06 05:05 352256 ----a-w- c:\program files\Common Files\System\ado\msadomd.dll
2012-07-11 20:35 . 2012-06-06 05:05 212992 ----a-w- c:\program files\Common Files\System\msadc\msadco.dll
2012-07-11 20:35 . 2012-06-06 05:03 805376 ----a-w- c:\windows\system32\cdosys.dll
2012-07-04 13:29 . 2009-05-18 12:17 26600 ----a-w- c:\windows\system32\drivers\GEARAspiWDM.sys
2012-07-04 13:29 . 2008-04-17 11:12 107368 ----a-w- c:\windows\system32\GEARAspi.dll
2012-07-04 13:28 . 2012-07-04 13:28 -------- d-----w- c:\program files\iPod
2012-07-04 13:28 . 2012-07-04 13:29 -------- d-----w- c:\program files\iTunes
2012-06-24 15:50 . 2011-02-19 06:30 805376 ----a-w- c:\windows\system32\FntCache.dll
2012-06-24 15:50 . 2011-02-19 06:30 739840 ----a-w- c:\windows\system32\d2d1.dll
2012-06-24 15:46 . 2012-06-02 22:19 53784 ----a-w- c:\windows\system32\wuauclt.exe
2012-06-24 15:46 . 2012-06-02 22:19 45080 ----a-w- c:\windows\system32\wups2.dll
2012-06-24 15:46 . 2012-06-02 22:19 1933848 ----a-w- c:\windows\system32\wuaueng.dll
2012-06-24 15:46 . 2012-06-02 22:12 2422272 ----a-w- c:\windows\system32\wucltux.dll
2012-06-24 15:46 . 2012-06-02 22:19 35864 ----a-w- c:\windows\system32\wups.dll
2012-06-24 15:46 . 2012-06-02 22:19 577048 ----a-w- c:\windows\system32\wuapi.dll
2012-06-24 15:46 . 2012-06-02 22:12 88576 ----a-w- c:\windows\system32\wudriver.dll
2012-06-24 15:46 . 2012-06-02 14:19 171904 ----a-w- c:\windows\system32\wuwebv.dll
2012-06-24 15:46 . 2012-06-02 14:12 33792 ----a-w- c:\windows\system32\wuapp.exe
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(((((((((((((((((((((((((((((((((((((((( Find3M Report ))))))))))))))))))))))))))))))))))))))))))))))))))))
.
2012-07-03 12:46 . 2012-04-14 10:59 22344 ----a-w- c:\windows\system32\drivers\mbam.sys
2012-07-01 22:43 . 2012-04-02 09:06 426184 ----a-w- c:\windows\system32\FlashPlayerApp.exe
2012-07-01 22:43 . 2012-01-22 21:41 70344 ----a-w- c:\windows\system32\FlashPlayerCPLApp.cpl
2012-05-15 10:26 . 2012-06-02 21:49 883008 ----a-w- c:\windows\system32\nvgenco32.dll
2012-05-15 10:26 . 2012-06-02 21:49 8105280 ----a-w- c:\windows\system32\nvwgf2um.dll
2012-05-15 10:26 . 2012-06-02 21:49 5982528 ----a-w- c:\windows\system32\nvcuda.dll
2012-05-15 10:26 . 2012-06-02 21:49 2524992 ----a-w- c:\windows\system32\nvcuvid.dll
2012-05-15 10:26 . 2012-06-02 21:49 2445120 ----a-w- c:\windows\system32\nvcuvenc.dll
2012-05-15 10:26 . 2012-06-02 21:49 2368832 ----a-w- c:\windows\system32\nvapi.dll
2012-05-15 10:26 . 2012-06-02 21:49 19607872 ----a-w- c:\windows\system32\nvoglv32.dll
2012-05-15 10:26 . 2012-06-02 21:49 17551680 ----a-w- c:\windows\system32\nvcompiler.dll
2012-05-15 10:26 . 2012-06-02 21:49 15322432 ----a-w- c:\windows\system32\nvd3dum.dll
2012-05-15 10:26 . 2012-06-02 21:49 11354944 ----a-w- c:\windows\system32\drivers\nvlddmkm.sys
2012-05-15 10:26 . 2012-06-02 21:49 1000768 ----a-w- c:\windows\system32\nvdispco32.dll
2012-05-15 10:26 . 2012-03-13 21:12 61248 ----a-w- c:\windows\system32\OpenCL.dll
2012-05-15 09:28 . 2012-06-11 22:19 645440 ----a-w- c:\windows\system32\nvvsvc.exe
2012-05-15 09:28 . 2012-06-11 22:19 62272 ----a-w- c:\windows\system32\nvshext.dll
2012-05-15 09:28 . 2012-06-11 22:19 108352 ----a-w- c:\windows\system32\nvmctray.dll
2012-05-15 09:28 . 2012-06-11 22:19 3931456 ----a-w- c:\windows\system32\nvcpl.dll
2012-05-15 09:27 . 2012-06-11 22:19 2759488 ----a-w- c:\windows\system32\nvsvc.dll
2012-05-15 01:21 . 2012-05-15 01:21 423744 ----a-w- c:\windows\system32\nvStreaming.exe
2012-05-01 04:44 . 2012-06-13 12:06 164352 ----a-w- c:\windows\system32\profsvc.dll
2012-04-28 03:17 . 2012-06-13 12:07 183808 ----a-w- c:\windows\system32\drivers\rdpwd.sys
2012-04-26 04:45 . 2012-06-13 12:06 58880 ----a-w- c:\windows\system32\rdpwsx.dll
2012-04-26 04:45 . 2012-06-13 12:06 129536 ----a-w- c:\windows\system32\rdpcorekmts.dll
2012-04-26 04:41 . 2012-06-13 12:06 8192 ----a-w- c:\windows\system32\rdrmemptylst.exe
2012-04-24 04:36 . 2012-06-13 12:06 140288 ----a-w- c:\windows\system32\cryptsvc.dll
2012-04-24 04:36 . 2012-06-13 12:06 1158656 ----a-w- c:\windows\system32\crypt32.dll
2012-04-24 04:36 . 2012-06-13 12:06 103936 ----a-w- c:\windows\system32\cryptnet.dll
2012-04-18 17:08 . 2012-06-02 21:49 27968 ----a-w- c:\windows\system32\nvhdap32.dll
2012-04-18 17:08 . 2012-06-02 21:49 148800 ----a-w- c:\windows\system32\drivers\nvhda32v.sys
2012-04-18 17:08 . 2012-06-02 21:49 876864 ----a-w- c:\windows\system32\nvhdagenco3220103.dll
2012-02-21 15:43 . 2012-02-21 15:43 200846 ----a-w- c:\program files\RuntimeSetup.exe
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((((((((((((((((((((((((((((((((((((( Reg Loading Points ))))))))))))))))))))))))))))))))))))))))))))))))))
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*Note* empty entries & legit default entries are not shown
REGEDIT4
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[HKEY_LOCAL_MACHINE\software\microsoft\windows\currentversion\explorer\shelliconoverlayidentifiers\ SkyDrive1]
@="{F241C880-6982-4CE5-8CF7-7085BA96DA5A}"
[HKEY_CLASSES_ROOT\CLSID\{F241C880-6982-4CE5-8CF7-7085BA96DA5A}]
2012-07-13 07:56 220632 ----a-w- c:\users\Chris J. Hudson\AppData\Local\Microsoft\SkyDrive\16.4.6003.0710\SkyDriveShell.dll
.
[HKEY_LOCAL_MACHINE\software\microsoft\windows\currentversion\explorer\shelliconoverlayidentifiers\ SkyDrive2]
@="{A0396A93-DC06-4AEF-BEE9-95FFCCAEF20E}"
[HKEY_CLASSES_ROOT\CLSID\{A0396A93-DC06-4AEF-BEE9-95FFCCAEF20E}]
2012-07-13 07:56 220632 ----a-w- c:\users\Chris J. Hudson\AppData\Local\Microsoft\SkyDrive\16.4.6003.0710\SkyDriveShell.dll
.
[HKEY_LOCAL_MACHINE\software\microsoft\windows\currentversion\explorer\shelliconoverlayidentifiers\ SkyDrive3]
@="{BBACC218-34EA-4666-9D7A-C78F2274A524}"
[HKEY_CLASSES_ROOT\CLSID\{BBACC218-34EA-4666-9D7A-C78F2274A524}]
2012-07-13 07:56 220632 ----a-w- c:\users\Chris J. Hudson\AppData\Local\Microsoft\SkyDrive\16.4.6003.0710\SkyDriveShell.dll
.
[HKEY_CURRENT_USER\SOFTWARE\Microsoft\Windows\CurrentVersion\Run]
"Sidebar"="c:\program files\Windows Sidebar\sidebar.exe" [2010-11-20 1174016]
"B34A1393B739BBBD2BCFD7ABD1C5D2E2D57962B4._service_run"="c:\users\Chris J. Hudson\AppData\Local\Google\Chrome\Application\chrome.exe" [2012-07-10 1250328]
"MobileDocuments"="c:\program files\Common Files\Apple\Internet Services\ubd.exe" [2012-02-23 59240]
"SkyDrive"="c:\users\Chris J. Hudson\AppData\Local\Microsoft\SkyDrive\SkyDrive.exe" [2012-07-13 238552]
"TBPanel"="c:\program files\Vtune\TBPanel.exe" [2010-09-02 2158592]
"chromium"="c:\users\Chris J. Hudson\AppData\Local\Google\Chrome\Application\chrome.exe" [2012-07-10 1250328]
.
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurrentVersion\Run]
"RTHDVCPL"="c:\program files\Realtek\Audio\HDA\RtHDVCpl.exe" [2011-12-13 11487848]
"Adobe ARM"="c:\program files\Common Files\Adobe\ARM\1.0\AdobeARM.exe" [2012-01-03 843712]
"APSDaemon"="c:\program files\Common Files\Apple\Apple Application Support\APSDaemon.exe" [2012-05-30 59280]
"AVP"="c:\program files\Kaspersky Lab\Kaspersky Internet Security 2012\avp.exe" [2011-04-24 202296]
"Malwarebytes' Anti-Malware"="c:\program files\Malwarebytes' Anti-Malware\mbamgui.exe" [2012-07-03 462920]
"RIMBBLaunchAgent.exe"="c:\program files\Common Files\Research In Motion\USB Drivers\RIMBBLaunchAgent.exe" [2011-11-02 90448]
"iTunesHelper"="c:\program files\iTunes\iTunesHelper.exe" [2012-06-07 421776]
.
[HKEY_LOCAL_MACHINE\software\microsoft\windows\currentversion\policies\system]
"ConsentPromptBehaviorAdmin"= 5 (0x5)
"ConsentPromptBehaviorUser"= 3 (0x3)
"EnableUIADesktopToggle"= 0 (0x0)
.
[HKEY_LOCAL_MACHINE\system\currentcontrolset\control\lsa]
Security Packages REG_MULTI_SZ kerberos msv1_0 schannel wdigest tspkg pku2u livessp
.
R2 nvUpdatusService;NVIDIA Update Service Daemon;c:\program files\NVIDIA Corporation\NVIDIA Update Core\daemonu.exe [x]
R2 SkypeUpdate;Skype Updater;c:\program files\Skype\Updater\Updater.exe [x]
R3 TsUsbFlt;TsUsbFlt;c:\windows\system32\drivers\tsusbflt.sys [x]
R3 TsUsbGD;Remote Desktop Generic USB Device;c:\windows\system32\drivers\TsUsbGD.sys [x]
R4 wlcrasvc;Windows Live Mesh remote connections service;c:\program files\Windows Live\Mesh\wlcrasvc.exe [x]
S1 kl2;kl2;c:\windows\system32\DRIVERS\kl2.sys [x]
S1 vwififlt;Virtual WiFi Filter Driver;c:\windows\system32\DRIVERS\vwififlt.sys [x]
S2 AdobeARMservice;Adobe Acrobat Update Service;c:\program files\Common Files\Adobe\ARM\1.0\armsvc.exe [x]
S2 MBAMService;MBAMService;c:\program files\Malwarebytes' Anti-Malware\mbamservice.exe [x]
S2 Stereo Service;NVIDIA Stereoscopic 3D Driver Service;c:\program files\NVIDIA Corporation\3D Vision\nvSCPAPISvr.exe [x]
S3 AtcL001;NDIS Miniport Driver for Atheros L1 Gigabit Ethernet Controller;c:\windows\system32\DRIVERS\l160x86.sys [x]
S3 klmouflt;Kaspersky Lab KLMOUFLT;c:\windows\system32\DRIVERS\klmouflt.sys [x]
S3 MBAMProtector;MBAMProtector;c:\windows\system32\drivers\mbam.sys [x]
S3 NVHDA;Service for NVIDIA High Definition Audio Driver;c:\windows\system32\drivers\nvhda32v.sys [x]
S3 SaiHFF0C;SaiHFF0C;c:\windows\system32\DRIVERS\SaiHFF0C.sys [x]
S3 SaiUFF0C;SaiUFF0C;c:\windows\system32\DRIVERS\SaiUFF0C.sys [x]
S3 tihub3;TI USB3 Hub Service;c:\windows\system32\DRIVERS\tihub3.sys [x]
S3 tixhci;TI XHCI Service;c:\windows\system32\DRIVERS\tixhci.sys [x]
S3 vwifimp;Microsoft Virtual WiFi Miniport Service;c:\windows\system32\DRIVERS\vwifimp.sys [x]
.
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--- Other Services/Drivers In Memory ---
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*NewlyCreated* - 13165922
*Deregistered* - 13165922
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[HKEY_LOCAL_MACHINE\software\microsoft\windows nt\currentversion\svchost]
HPZ12 REG_MULTI_SZ Pml Driver HPZ12 Net Driver HPZ12
.
Contents of the 'Scheduled Tasks' folder
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2012-07-15 c:\windows\Tasks\GoogleUpdateTaskUserS-1-5-21-4242454274-3306585242-3044636838-1000Core1cd0911b347170f.job
- c:\users\Chris J. Hudson\AppData\Local\Google\Update\GoogleUpdate.exe [2012-01-29 17:14]
.
2012-07-15 c:\windows\Tasks\GoogleUpdateTaskUserS-1-5-21-4242454274-3306585242-3044636838-1000UA1cd0911b521aa62.job
- c:\users\Chris J. Hudson\AppData\Local\Google\Update\GoogleUpdate.exe [2012-01-29 17:14]
.
.
------- Supplementary Scan -------
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uInternet Settings,ProxyOverride = *.local
IE: Add to Anti-Banner - c:\program files\Kaspersky Lab\Kaspersky Internet Security 2012\ie_banner_deny.htm
IE: E&xport to Microsoft Excel - c:\progra~1\MICROS~3\Office12\EXCEL.EXE/3000
TCP: DhcpNameServer = 192.168.0.1
.
- - - - ORPHANS REMOVED - - - -
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Toolbar-{D4027C7F-154A-4066-A1AD-4243D8127440} - (no file)
SafeBoot-13165922.sys
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.
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--------------------- LOCKED REGISTRY KEYS ---------------------
.
[HKEY_USERS\.Default\Software\Microsoft\Internet Explorer\Approved Extensions]
@Denied: (2) (LocalSystem)
"{18DF081C-E8AD-4283-A596-FA578C2EBDC3}"=hex:51,66,7a,6c,4c,1d,38,12,72,0b,cc,
1c,9f,a6,ed,07,da,80,b9,17,89,70,f9,d7
"{59273AB4-E7D3-40F9-A1A8-6FA9CCA1862C}"=hex:51,66,7a,6c,4c,1d,38,12,da,39,34,
5d,e1,a9,97,05,de,be,2c,e9,c9,ff,c2,38
"{9030D464-4C02-4ABF-8ECC-5164760863C6}"=hex:51,66,7a,6c,4c,1d,38,12,0a,d7,23,
94,30,02,d1,0f,f1,da,12,24,73,56,27,d2
"{9FDDE16B-836F-4806-AB1F-1455CBEFF289}"=hex:51,66,7a,6c,4c,1d,38,12,05,e2,ce,
9b,5d,cd,68,0d,d4,09,57,15,ce,b1,b6,9d
"{AE805869-2E5C-4ED4-8F7B-F1F7851A4497}"=hex:51,66,7a,6c,4c,1d,38,12,07,5b,93,
aa,6e,60,ba,0b,f0,6d,b2,b7,80,44,00,83
"{E33CF602-D945-461A-83F0-819F76A199F8}"=hex:51,66,7a,6c,4c,1d,38,12,6c,f5,2f,
e7,77,97,74,03,fc,e6,c2,df,73,ff,dd,ec
"{FF059E31-CC5A-4E2E-BF3B-96E929D65503}"=hex:51,66,7a,6c,4c,1d,38,12,5f,9d,16,
fb,68,82,40,0b,c0,2d,d5,a9,2c,88,11,17
.
[HKEY_USERS\.Default\Software\Microsoft\Internet Explorer\ApprovedExtensionsMigration]
@Denied: (2) (LocalSystem)
"Timestamp"=hex:50,bc,ba,be,4a,10,cd,01
.
[HKEY_USERS\.Default\Software\Microsoft\Internet Explorer\User Preferences]
@Denied: (2) (LocalSystem)
"2D53CFFC5C1A3DD2E97B7979AC2A92BD59BC839E81"=hex:01,00,00,00,d0,8c,9d,df,01,15,
d1,11,8c,7a,00,c0,4f,c2,97,eb,01,00,00,00,4c,a6,9a,68,6f,8f,a8,4f,94,1d,83,\
"88D7D0879DAB32E14DE5B3A805A34F98AFF34F5977"=hex:01,00,00,00,d0,8c,9d,df,01,15,
d1,11,8c,7a,00,c0,4f,c2,97,eb,01,00,00,00,4c,a6,9a,68,6f,8f,a8,4f,94,1d,83,\
.
[HKEY_USERS\S-1-5-21-4242454274-3306585242-3044636838-1000\Software\Microsoft\Windows\CurrentVersion\Explorer\FileExts\.eml\UserChoice]
@Denied: (2) (LocalSystem)
"Progid"="WindowsLiveMail.Email.1"
.
[HKEY_USERS\S-1-5-21-4242454274-3306585242-3044636838-1000\Software\Microsoft\Windows\CurrentVersion\Explorer\FileExts\.vcf\UserChoice]
@Denied: (2) (LocalSystem)
"Progid"="WindowsLiveMail.VCard.1"
.
[HKEY_LOCAL_MACHINE\SYSTEM\ControlSet001\Control\Class\{4D36E96D-E325-11CE-BFC1-08002BE10318}\0000\AllUserSettings]
@Denied: (A) (Users)
@Denied: (A) (Everyone)
@Allowed: (B 1 2 3 4 5) (S-1-5-20)
"BlindDial"=dword:00000000
.
[HKEY_LOCAL_MACHINE\SYSTEM\ControlSet001\Control\PCW\Security]
@Denied: (Full) (Everyone)
.
Completion time: 2012-07-15 16:55:41
ComboFix-quarantined-files.txt 2012-07-15 15:55
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Pre-Run: 69,641,908,224 bytes free
Post-Run: 69,836,226,560 bytes free
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- - End Of File - - CBA941CB4072686B9A5CE0BBD947CDDA

Thanks gregrocker, I was not ignoring you before, just short of time and missed your previous post! :)
Will try that and report back.

EDIT: The disc with the funny 'clicking' noises (which I rescued from a kaput Sony Viao) is not bootable, merely spare external storage.