Windows cannot access the specified device, path, file

2 of my programs cannot be started they give this error, they were working fine till last 2 days ago when suddenly this error started appearing.

ERROR
Windows cannot access the specified device, path, or file. You may not have the appropriate permissions to access the item.

I tried reinstalling them but the same problem, I am the admin of this machine & the UAC remains turned off since 1st install.
I even have tried right click> run as admin it still does not work.

Tews said:

Take ownership of the files.. See Brinks tutorial on this -=> here

Applied the reg hack took the ownership but it still shows the same error, event viewer does not mention this application (IDM) in error.

I checked for the permission & yes they are the same as you have mentioned.
SYSTEM - Full Control
Administrators - Full Control
Users - Read & execute / Read

I tried running in compatibility mode XPsp3 but the problem remains as it is.

Could it be the Kaspersky firewall blocking the application to run?

Are you launching these apps from a shortcut? Try launching the app by manually double clicking the exe file in the program folder.

hacku said:

Are you launching these apps from a shortcut? Try launching the app by manually double clicking the exe file in the program folder.

Tried both ways but it does not work, actually IDM automatically start when it catches a link from the browser that needs to be downloaded via IDM.