Hmm well living where I do now my deskies are a long way away and I have to rely on my "prostitute" 17" Asus ROG which I find is better than my other lappies but in fairness is reasonably capable of doing what my deskies do mainly because I have access to a second internal drive and separate dedicated GPU.
One thing is for sure it knocks spots off my other machines for speed :)
As for dealing with them I really don't have that much in the way of maintenance and taking them down ok it is a bit of a fiddle but hey I like a challenge. Mind you I do miss the big screen