They probably are not taking up very much space, so unless a file has a .tmp, .~mp, .bac or .bak extension on them, I'd advise you to just leave them alone. There are a lot more space eating files on your HD that you could remove, if that's what you're all about.
Like all those nebulous sound files and Sample files installed by Windows. I once wrote a Batch file to delete all those POC files. The one thing you DO NOT want to delete are all your "Setup Log" files.
Windows own "Disk Cleanup" program if run in extended mode, will get rid of tons of crap out of your PC.
It can even remove the "Windows Old" folder, if you have one. Check it out?
Happy Holidays mate!
TechnoMage 
PS: I found the How-To, run Disk Cleanup in Extended Mode, where I had posted it on another forum, several years ago. Here it is: (copy or print)
Run Disk Cleanup in Extended Mode
Set up “Disk Cleanup” to run in “Extended Mode”
Here's how Disk Cleanup comes from MS:
%windir%\system32\cleanmgr.exe
When run like this, its Cleanup is very limited.
Create the above shortcut on your desktop and then you can modify it, so that it becomes “Extended Disk Cleanup”.
Step one is to right click on the shortcut, select properties and then change/edit the syntax of the shortcut to read:
%SystemRoot%\System32\Cmd.exe /c Cleanmgr /sageset:65
Save it!
Then you need to run the shortcut and select everything BUT 'Setup.log', because you'll need that if you ever intend to uninstall any programs.
On that first run, you're only setting up how you want Disk Cleanup to run, but nothing will be deleted.
Now right click on the shortcut again, select Properties, and again change/edit it to read:
%SystemRoot%\System32\Cmd.exe /c Cleanmgr /sagerun:65
Save it!
(you've changed /sageset:65 to /sagerun:65 )
Now when you run the shortcut, everything that you selected in the previous operation, will be deleted. At this point you have a Shortcut to “Extended Disk Cleanup” on your desktop. The shortcut can be copied to the STARTUP folder, so it runs on every boot-up of the computer, for a really Clean PC.
That works good, for those who either can-not or will-not do their own HD maintenance. I set that up for my elderly customers, who can never remember to run their own Maintenance.
There are other programs, like Windows Utilities (WinUtils), that do a more thorough job of finding and removing junk, but they have to be run manually, and they don't come for FREE with Windows, and many of those programs are NOT free, but can cost up to $49.
Quote