New
#11
Yay!!!
I finally came back to say, I finally got this fixed! Just last week. I had to fix another problem, and information I found online told me to start msconfig.exe and go to the Startup tab to disable something. While I was there, I noticed other items that seemed to refer to a mouse I no longer use. I felt it was safe to disable them, and sure enough, now my settings are being saved! What a relief to be rid if this silly problem.
Looking back, it seems that other advice above was similar, but in my case I needed to DISABLE mouse software (or something)--and I was pretty sure I had already uninstalled the software in question so I don't know what was going on. I disabled three items, one that said Intellipoint (can't recall exactly), so I don't know exactly what fixed it. Sorry to be so vague but I'm not at that computer now. I just encourage everyone to (carefully) try disabling (or enabling?) items they find in Startup.