2 monitor setup will my GTX780 handle this...

I sent this one back because I wasn't willing to get any 4k monitors,
Cool the heat
EVGA GeForce GTX TITAN X HYBRID graphics card - GF GTX TITAN X - 12 GB: Amazon.co.uk: Computers & Accessories

All in one :/
Well it's liquid cooling
Here Newegg has better spec's on the cards either that or go to evga's site and check them out,
EVGA GeForce GTX TITAN X 12G-P4-1999-KR 12GB HYBRID GAMING, "All in One" No Hassle Water Cooling, Just Plug and Play Graphics Card - Newegg.com

Nice clocks but it is a reference card so it won't oc much at all you'd have to get a superclocked card for that or ssc
EVGA - Products - EVGA GeForce GTX TITAN X SC GAMING - 12G-P4-2992-KR

EVGA - Products - EVGA GeForce GTX TITAN Z Superclocked - 12G-P4-3992-KR

Then get a Titan X and a 1200 P2, so you can add another Titan in 4 or 6 months.

If you never plan to add a 2nd card then the 1000 P2 is more then adequate.

The sooner the better :)

It`s also recommended to raise your memory to 32 GB

A 65" and 2 40" would be awesome, but personally, I think the 65" would be too big.

Keeping all the monitors the same size is the way to go.

But as they say, it`s your Euro :)

I'd say in the quoted area you just replied to the bottom 2 pick your budget point and go with it :)12G-P4-2992-KR is a nice card with oc possibilities with 2-4k monitors in mind yep it would be a good choice

No budget go for the 3992 can't go wrong.

Yep it's either that or sli a couple 980ti's seems the 1 titan 2992 is more straight forward :)