Is it possible ALL 6 USB ports to not work ?

Please update/complete your pc specs, so we can help you.

Lgee3ree said:

I have plugged in a device into all 6 ports and none work, even after a start up...

plug in another device for example keyboard/mouse/usb stick. Works?

Lgee3ree said:

Is it possible ALL 6 USB ports to not work ?

Yes. Very possible.

Your USB ports are all connected to one controller on the motherboard - usually part of the Southbridge chipset.

There is normally a setting in the BIOS that allows you to enable or disable that controller. You might look into that first.

There is also a driver that runs the USB controller. You can try reinstalling that driver to test. This can be done by "Removing" all the devices listed under USB in Device Manager and then restarting the computer.

And then there is the possibility that the controller chip or the Southbridge chip itself has be damaged. This can happen on motherboards with poor ElectroStaticProtection circuits where a static spark from handling the USB plug fries the circuit.