Mouse/Keyboard freezes.

So what happens is my keyboard/mouse freezes but my browser still loads and I can still hear music.
What makes me think that my browser loads? I can see my friends pm me and hear the *boop* sound in Facebook.

My mouse is wired while my keyboard is wireless.

Things I've tried
-Updating driver for Mouse and Keyboard
-Sfc /scannow
-Unplug and plug the Mouse and Keyboard

What I think seem to be the issue,
Itunes
League of Legends

I've had iTunes on every time this happens. Even without LoL running, it even freezes on the desktop/browser only.
And most of the time I've been playing League of Legends and it freezes in game.

I've done sfc /scannow nothing seems to be the problem.

But I've checked Event Viewer and I've seen this.

I was pretty sure at 10:30pm onwards until 11:45pm I was playing League of Legends with iTunes open.

Hope you guys can help me out!

It's a generic Samsung mouse and a Logitech Wireless Keyboard

Well, it just froze again today, while playing Torchlight 2 -_-.

Okay now it froze a few seconds later after Skype updated.

No errors there too.

Okay so I just crashed after generating a system health report. My mouse and keyboard just froze while it was still generating the report.
Also what should I do if this happens again? Should I restart immediately or what?

I haven't froze yet. I've plugged the mouse in the front port.