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The basic essential is to make backups of all your data, if there is a problem and you lose the Vista system - you can use the disk you have to recover - if you lose your own data you are
To make things easier to restore Vista if you do have an issue you could create a system image that would reduce the re-install time dramatically
Most users here use a free version of Macrium Reflect for these Images Imaging with free Macrium
As for the size needed for the image right click on your root of the System Drive, [Normally C:], and check properties this will show you the size used - this is the maximum space you will need for a backup/Image - most backups/Images will perform some compression/cleaning so checking the program will allow you to reduce the space required