Word Hyperlink Kills Website in Browser

I would probably have to have a copy of the markup and the file in front of me. It seems like something is cached or a cookie is stored upon attempting to go to that page, because it doesn't make sense that the issue expires after approximately half an hour...wait, what?!

The other interesting part is once one computer on the network errors out no computer on the same network can access the site either for approx. 30 min.

This just blows me away... but I have a thought!
Were all the several computers that you replicate the issue on tied to the same or similar networks as the initial one?

Did you confirm that the other two computers in your shop were not able to access the site for approximately thirty minutes after clicking the link in the Office document? Were they on the same network together?
Is this consistent on all of the other networks too? As in, the other computers on the same network as the one that clicked the link from the Office document also somehow caught the illness?

It has to be DNS related.

I can't reproduce it unfortunately. My 2010 key is missing and Office 365 didn't seem to cut it.

dlc41 said:

I would have to agree but why would it work fine in IE, Firefox and Outlook but not Word or Excel?

Application layer. The DNS is obfuscated or something and IE has a different approach with DNS considerations to Firefox.

I thought you meant that Word or Excel will trigger this behaviour in IE but not the other browsers, and IE is fine without Word or Excel having been in the equation from the beginning.
So, I don't know, maybe because it's all Microsoft software, there's something funky going on with the application layer that makes its way to the transport layer and from there the router doesn't discriminate with Office's chosen resolution or something like that, and so IE stubbornly sticks to what Office decided on and does not request another resolution. The router then assumes that IE knows best when it comes to the resolution and for what ever reason hands out that corrupted/bad resolution to any other networked computer, or the first computer itself shares its table instantly but that doesn't make sense. None of this does.

It seems like if this were correct then the error should happen near instantaneously and not take its time, if that is any supporting indication.

I don't get how this can be possible.
Does flushing DNS or changing DNS server mitigate it?

dlc41 said:

if you put the hyperlink into Word or Excel and click on it none of the browsers will open the site, they all error out saying can't load the page, and no computer on the same network can access the site for approx. 30 min.

I see. I thought you were trying to say that only IE was doing that after having clicked the link in Word or Excel.

Well, if Office doesn't resolve the hyperlink prior to shelling it off to your browser of choice, then I am stumped.
My guess still applies just minus the Firefox and IE stubbornness bit. Theoretically speaking, if the router thinks it has the right (corrupted) resolution in its tables it would not matter what browser or device tries to load the page.

Flushed DNS, cleared and deleted all history files, tried different DNS servers, nothing works so far.

I...see. Has any attempt been made to put the website elsewhere?