DNS Fails after any change to Adapter settings.

I have a problem that is just killing me. If I modify any IPv4 setting in my wireless adapter (or wired for that matter), I lose DNS lookup capability. This surfaced sometime ago but it is a real problem now. I bought a new Wireless-N adapter and cannot install it because "any" change at all results in the DNS Failure. I have done everything I could find with regard to suggestions: I uninstalled Nortorn Internet Security. I reset the TCP stack, I even reset permissions on the Registry. I manually cleaned up all the old adapter items in the registry. Nothing has worked. Also, I uninstalled Windows Updates back to October of last year and tried uninstalling any software that was installed in the last 3 months. So, I am stuck - reinstalling windows 7 ultimate is just not an option. I have IIS setup (test bed for 4 live websites I maintain) , a mail daemon and tons of other programs, it would take me weeks if not months to get everything working again. So, anyone have any suggestions. Note: I do not use the Broadcom Wired Connection, but I need to keep it in a disconnected state (not disabled) because the Mail Server (Mdaemon) stupidly only checks for a wired adapter and won't even startup without one - even though it works just fine with a wireless.

Here is my ipconfig /all output:

Windows IP Configuration
Host Name . . . . . . . . . . . . : Bilbo
Primary Dns Suffix . . . . . . . :
Node Type . . . . . . . . . . . . : Hybrid
IP Routing Enabled. . . . . . . . : No
WINS Proxy Enabled. . . . . . . . : No
Ethernet adapter Local Area Connection:
Media State . . . . . . . . . . . : Media disconnected
Connection-specific DNS Suffix . :
Description . . . . . . . . . . . : Broadcom NetLink (TM) Gigabit Ethernet
Physical Address. . . . . . . . . : 00-25-64-E3-60-06
DHCP Enabled. . . . . . . . . . . : No
Autoconfiguration Enabled . . . . : Yes

Wireless LAN adapter Wireless Network Connection:
Connection-specific DNS Suffix . :
Description . . . . . . . . . . . : Realtek RTL8192SU Wireless LAN 802.11n USB 2.0 Network Adapter #6
Physical Address. . . . . . . . . : 00-E0-4C-81-92-52
DHCP Enabled. . . . . . . . . . . : No
Autoconfiguration Enabled . . . . : Yes
IPv6 Address. . . . . . . . . . . : 2601:a:2400:4a:edb0:7078:4533:46f3(Preferred)
IPv6 Address. . . . . . . . . . . : fdd0:bc54:2c1f:0:edb0:7078:4533:46f3(Preferred)
Temporary IPv6 Address. . . . . . : 2601:a:2400:4a:8dd5:cf92:9f52:7503(Preferred)
Temporary IPv6 Address. . . . . . : fdd0:bc54:2c1f:0:8dd5:cf92:9f52:7503(Preferred)
Link-local IPv6 Address . . . . . : fe80::edb0:7078:4533:46f3%26(Preferred)
IPv4 Address. . . . . . . . . . . : 192.168.254.1(Preferred)
Subnet Mask . . . . . . . . . . . : 255.255.255.0
Default Gateway . . . . . . . . . : fe80::5a6d:8fff:fe0d:6deb%26
192.168.254.254
DHCPv6 IAID . . . . . . . . . . . : 503373900
DHCPv6 Client DUID. . . . . . . . : 00-01-00-01-12-D4-7D-B0-00-25-64-E3-60-06
DNS Servers . . . . . . . . . . . : 2620:0:ccc::2
2620:0:ccd::2
208.67.222.222
208.67.220.220
NetBIOS over Tcpip. . . . . . . . : Enabled

Already use OpenDNS servers Router and PC. Also, I tried DHCP and it did not make any difference. Also, DNS Client was cycled, etc. So, been there done that. Just couldn't list everything I tried. All, the standard suggestions did not solve the problem. Something is screwed up in the DNS association with adapters but I cannot for the life of me figure it out. Thanks for the suggestion though. Jack