The windows installer turns defrag off. You should never do any of those tweaks unless you want to create a genuine mess. The only 2 things I have done with my 5 SSDs is to get rid of the hiberfile (the command is powercfg -h off) and I move my user folders to the HDD. That's all. And they all work beautifully. I even run some in IDE mode, but AHCI is generally advised.