Is it worth it defragging 100+ GB?

Hi there! I'm new to the forums :)

My computer was running a little bit slow so I decided to download Piriform's Defraggler.
Upon analyzing my 2TB WD Blue drive (my OS drive and the one I am currently using) I noticed that There was 110GB of fragmented files.
There are 2,726 fragmented files and 19,853 total fragments. Defraggler states that my drive is 16% fragmented.

I'm not sure if the amount of fragmented gigs is something to worry about or not. Timewise, I can't leave my PC on all night because it is in my bedroom, not too far from me. The whirring would keep me awake.

How should I go about this? Should I leave it be? Any general help on the subject of defragging?

Thanks for any help!

Thanks much for all the information! It's much appreciated and very helpful :)

Brien is right. You have no idea what a SSD can do for your computer.
Buy a 128 G SSD for Windows and programs and use the HDD for data. You'll will have the speed of a SSD and the space of a HDD.
I have one of these and they are in offer (US$56) PNY CS1311 2.5 SSD7CS1311-120-RB-Newegg.com
Read this thread
Is recommended new drives compatible? Solved - Windows 7 Help Forums

I've considered an SSD but I'm not sure I can afford one at the moment. Do you have any suggestions for a budget drive?
I'm planning a full upgrade/rebuild of my PC, but it's not doable at this point in time. I'm currently seventeen and don't have a steady source of income to fulfill the monetary needs for upgrading.
I think it's worth noting that my WD Blue drives are hybrid SSHD drives.
I'll take a look at the thread, thanks!

As many people are replacing the HDD or just adding a SSD, the prices are high.
I've bought my PNY CS1311 for only US$ 39 last year and I saw it for US$ 75 last week.
Believe me, US$56 is a budget price for a good SSD.
With a SSD, boot time dropped from 3 minutes to 30 seconds and programs opens instantly.

I'll definitely look in to getting one, thanks!
And, although it's not relevant, I was curious if you'd mind taking a look at my current specs and the build I'm looking to make? Or should I make a new thread about this all together?
I'm having trouble prioritizing my upgrades. So far, I've only upgraded my graphics card being that I game a good amount and that was most relevant.

You have a good CPU ( i5-2500k) and a good MB (ASUS P8B75-V).
I have a 6 year old sandybrige and a new skylake and there is no significant difference between the two.
On a gamer computer, the sky is the limit (or I may say the bank account is the limit).
And remember, at high end, you pay double to have 20% performance increase and a few months later, with a new state of the art, it will became a budget.

If you haven't done it yet, as you have a unlocked CPU, you can do a 10 to 15 % overclock (don't do it higher as you'll need to increase voltages to get stability, generating a lot more heat and it can easily damage the components)

I'll look in to overclocking. My current build (Old Specs - Album on Imgur a list of when I bought the parts, ignore the GPU and hard drive) is quite off from what I am hoping to upgrade to in the future (Finalized Build - FrankRDs Saved Part List - Core i7-7700K 4.2GHz Qua... - PCPartPicker).
Any suggestions on some cheaper alternatives in my list?
Once again, thanks for taking to time to help me out :)