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#11
I agree. Unless you're overclocking it's not really a huge deal.
However, there will absolutely be a noticeable difference going from the 5300 to the 6400. Will it be epic? Most likely not but there will be a slight difference.
Right now though, don't mix and match the RAM. That generally causes way more issues than the gain. Stick to the 4GB's till you get the rest of the 6400's. When you've got those, throw them all in at once. Dropping down to 2GB of RAM regardless of speed is going to take away from your current performance.