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AviSynth
For the adventurous types interested in video encoding, there's a 64 bit version of AviSynth:
SEt's Avisynth 2.5.8 MT compiled for *X86_64*, Latest Build 4/16/2010 - Doom9's Forum
It's one of those tools that many video encoders use to do filtering, cropping etc..
There are several encoders that are migrating to 64 bits also such as x264.
Seems like it's still at the stage for people who want to play around and try to get the chain of 64 bit programs to work. If they get it smoothed out though, it should deliver some of the promise of 64 bit speed. It's my understanding it's implemented using Intel compiler to utilize inline asm for speed.