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#11
Not a good idea to run 2 anti-viruses as they can actually conflict with each other and leave you open to infection.
Rule of thumb 1 only of each of the following: anti-virus, firewall*, pop-up blocker, anti-phishing filter.
A couple of anti-spyware applications is OK, however, minus any active protection** they may have.
*Exception is when you have an extra hardware firewall, as in a router.
** Exception, that I've found, SpywareBlaster.