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#51
I've been running MSE since it came out and have had no problems at all. I have this running constantly along with Windows Firewall.
One a week I run a MalwareBytes scan and then a SuperAntiSpyware scan. These usually come up with some adware cookies but nothing serious.
About once a month I run Sophos Anti Rootkit. This will usually show a few things but if I click on them I am advised not to remove them as they present no threat. (?)
Touch wood I've had no problems since adopting this routine.