Is It Best to Keep External Backup Hard Drive Powered Off

I always do a Cleanup and scan with my security programs before doing any kind of backup, imaging, cloning.

No sense in backing up garbage or infections.
 

My Computer My Computer

At a glance

Windows 10 Pro. 64/ version 1709 Windows 7 Pr...Intel i7-6800K @ 4.3Corsair Platinum 16 gig @2400EVGA GTX 1070 OC
Computer type
PC/Desktop
Computer Manufacturer/Model Number
Home made Desktop
OS
Windows 10 Pro. 64/ version 1709 Windows 7 Pro/64
CPU
Intel i7-6800K @ 4.3
Motherboard
ASUS X-99 Deluxe II
Memory
Corsair Platinum 16 gig @2400
Graphics Card(s)
EVGA GTX 1070 OC
Monitor(s) Displays
Asus 27" LED LCD/VE278Q
Screen Resolution
1920-1080 or 1280-720 HDMI
Hard Drives
INTEL SSD 730-240 Gb Sata 3.0/
PSU
EVGA Platium 1200W
Case
Phanteks Luxe Tempered Glass 8 fans/ one radiator
Cooling
XSPC/ Water Cooled CPU
Keyboard
Das 4 Professional
Mouse
Logitech M705/MX Anywhere 2-S
Internet Speed
100 mbits
Antivirus
Microsoft Security Essentials/ Malwarebytes Premium 3.0/ SAS
Browser
I.E. 11 default/Firefox/ ISP Time Warner Cable/Spectrum
Other Info
LG BluRay Burner/
Sound system-KLipsch-THX/
Icy Dock ssd Hot Swap bays.
I always do a Cleanup and scan with my security programs before doing any kind of backup, imaging, cloning.

No sense in backing up garbage or infections.

As I said, smarter than the average bear.
 

My Computer My Computer

At a glance

Win 7 Ultimate 64 bitIntel i7-3930KKingston HyperX Genesis 32GB Kit (8x4GB Modul...MSI R7850 Twin Frozr 2GD5/OC Radeon HD 7850 2...
Computer type
PC/Desktop
Computer Manufacturer/Model Number
Custom Build
OS
Win 7 Ultimate 64 bit
CPU
Intel i7-3930K
Motherboard
ASUS P9X79 WS
Memory
Kingston HyperX Genesis 32GB Kit (8x4GB Modules) 1600MHz DDR
Graphics Card(s)
MSI R7850 Twin Frozr 2GD5/OC Radeon HD 7850 2GB 256-bit GDDR
Sound Card
Asus Xonar Essence STX
Monitor(s) Displays
3x Asus VG248QE 24", Vizio 32" TV
Screen Resolution
1920 x 1080, ?
Hard Drives
Samsung 128GB 840 Pro SSD (1),
Samsung 4TB 850 EVO SSDs (4)
Samsung 4TB 850 EVO SSDs (16) external backup drives used in 2.5" hot swap bays in the computer.
PSU
Corsair HX750w
Case
Antec Two Hundred v2 (modified)
Cooling
Cooler Master GeminII S524 120mm (fan replaced with a 140mm)
Keyboard
Logitech G510s
Mouse
Logitech M525 (two in use)
Internet Speed
=< 32Mbps down, 8Mbps up
Antivirus
AVAST!, MBAM, SAS, Spybot S&D (all but MBAM free) Glary Util
Browser
IE11
Other Info
LSI 9211-8i HBA card (8 SATA III ports), 2.5" & 3.5" Hot Swap Bays, HooToo HT-CR001 PCI-E to USB 3.0 Internal Hub + 6 Slot Card Reader, and LG Model CH12LS28 BD-ROM Optical Drive. Also, ScanSnap S1500 ADF duplexing scanner, Canon 9000F flat bed scanner, Corsair SP2500 2.1 speakers, Samsung CLP 415nw laser color printer, Cyberpower PP2200SW UPS
LaybackBear, LadyF, yes, correct! My real time protection shields are ON during normal operations as well as during Macrium Reflect's on-the-fly-VSS backups.
 

My Computer My Computer

At a glance

Windows 7 Professional 64-bitDesktop i5; Acers i5 & i7desktop 16GB; 1 Acer 8GB & 1 Acer 16GB
Computer type
PC/Desktop
Computer Manufacturer/Model Number
Antec desktop; Acer Aspire laptops
OS
Windows 7 Professional 64-bit
CPU
Desktop i5; Acers i5 & i7
Memory
desktop 16GB; 1 Acer 8GB & 1 Acer 16GB
Hard Drives
1TB split into 2 equal partitions [OS and data] usable by RJS
Internet Speed
AT&T DSL
Browser
FF, GChrome, msIE
Other Info
Windows 7 Firewall, Emsisoft AM/AV, MSE [scan-only], SpywareBlaster, Ruiware/BillP combine
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