New
#610
Each subsequent Sysprep with Generalize switch does exactly the same: check for your Windows setup for existing hardware related information and remove it. It works and reacts exactly the same way regardless if it's done several times on the same install (useless but a geek way to test: sysprep, reboot to OOBE, reinstall drivers, sysprep again and so on), or on a restored image then afterwards restore the same image and sysprep again.
Sysprep does not care how many times it has been previously done.